ETBs self-route to the cytosol where they can intersect with the cell’s antigen presentation pathway. Molecular Templates is exploting the localization of ETBs to the cytosol to create a novel immuno-oncology approach we call Antigen Seeding Technology (AST). With AST, ETBs can be used to deliver foreign class I antigens to the cytosol of tumor cells where the antigens can be processed and displayed in complex with MHC class I molecules on the cell surface. Tumor cells expressing the foreign peptide/MHC class I complex on their cell surface can be targeted for destruction by native high-avidity cytotoxic T-cells resident in the patient.
Molecular Templates believes AST has the potential to be a “third” approach to immuno-oncology that is both distinct and complementary to the two predominant approaches to date: checkpoint inhibition and chimeric antigen receptors.